Course Objectives
1. Discuss how advancements in basic science lead to specific improvements in cancer care for women.
2. Review the description, classification, biology and significance of the chromosomal changes found
in cancer.
3. Discuss the current approaches and pitfalls to measuring ctDNA and how measuring ctDNA will improve the treatment of cancer and specifically GYN Cancers.
4. Discuss molecular biology of HPV infection including typing, oncogenicity, and detection.

Learning objectives: 
1) Distinguish between the different types of genome instability. (Medical Expert/Scholar)
2) Define, classify and measure the important characteristic of the chromosomal changes found in cancer and show an example in high grade serous ovarian cancer. (Medical Expert/Scholar)
3) Identify important characteristics of chromosomal instability in cancer and how they can be exploited for therapeutic advantage. (Medical Expert/Scholar)

Learning objectives:  
1) Describe how circulating tumour DNA (ctDNA) was discovered and measured. (Medical Expert/Scholar)
2) Discuss the current approaches and pitfalls to measuring ctDNA. (Medical Expert/Scholar)
3) Review examples of how measuring ctDNA will improve the treatment of cancer and specifically GYN Cancers.(Medical Expert/Scholar)

Learning objectives:  
1) Discuss a brief history and discovery of HPV as an oncogenic virus. (Medical Expert/Scholar) 
2) Review the molecular determinants of the different HPV types and the biology of their oncogenicity.  (Medical Expert/Scholar)
3) Describe the methods for identifying and measuring HPV infection in humans.(Medical Expert/Scholar)
4) Discuss new developments in molecular diagnosis of cervical cancer including novel epigenetic biomarkers.(Medical Expert/Scholar)

Learning objectives:
1) To appraise the role of incorporating robotic platform for surgery in Gynecologic Oncology. (Medical Expert/Scholar)
2) To appraise the currently published experiences regarding the societal and cost impacts with the incorporation of robotic surgical platforms. (Medical Expert/Scholar)
3) To support the appropriate use and acquisition of robotic surgical platforms. (Scholar/Health Advocate)

Learning objectives:
1) Identify the principle studies in ovarian cancer that lead to current recommendations of Parp inhibitor use in the recurrent and maintenance settings.
2) Understand the direction of current and future research for Parp inhibitors in the management of ovarian cancer.

Learning objectives:
1) To propose a new interdisciplinary ambulatory care model for gynecology oncology patients with or at risk of malignant bowel obstruction. (Medical Expert/Scholar)
2) To discuss the impact of a proactive oncology nurse-led ambulatory symptom management algorithm for gynecology oncology patients with or at risk of developing malignant bowel obstruction. (Medical Expert/Scholar)
3) To build capacity through shared knowledge with other cancer centres to improve quality of life for gynecology oncology patients with or at risk of malignant bowel obstruction. (Medical Expert/Collaborator)

Learning objectives:
1) Participants will be able to describe the mandate of the World Ovarian Cancer Coalition. 
2) Participants will be able to describe the scope of the Every Woman Study. 
3) Participants will be able to interpret the key findings identified in the Study. 

Learning objectives:
1) Distinguish the regulatory pathway for reference biologics from biosimilars. (Medical Expert/Scholar)
2) Evaluate the efficacy of biosimilars, approved by Health Canada, the EMA & FDA, vs reference biologic drugs for oncology indications. (Medical Expert/Scholar)
3) Apply relevant criteria for adopting biosimilars into oncology practice. (Medical Expert/Scholar)

Learning objectives:
1) Discuss the strengths and limitations of the recently published randomized trial assessing minimally invasive surgery for cervical cancer. (Medical Expert/Scholar)
2) Better assess the role of minimally invasive surgery for cervical cancer. (Medical Expert/Scholar)
3) Appraise their own outcomes after surgery for radical hysterectomy and support their approach or need for change in approach. (Medical Expert/Health Advocate)

Learning objectives:
1) To discuss the role of MR imaging in the management of locally advanced cervical cancer. (Medical Expert/Scholar)
2) To review the evidence supporting the use of MR-based brachytherapy for cervical cancer. (Medical Expert/Scholar)
3) To review new advances and innovations in cervical cancer management. (Medical Expert/Scholar)

Learning objectives:
1) Updated concepts on HPV infection and human disease and reasons for an indefinite ongoing need for HPV screening.
2) The role of self-sampling for HPV and use of the test for underdeveloped regions.
3) The role of cytology and HPV16/18 genotyping as triage tests for high-risk HPV positive women.
4) The potential added value of a new epigenetics molecular classifier to determine oncogenicity of HPV and risk of cervical cancer in screened women.

Learning objectives:
1) Summarize the complex and evolving nomenclature used to describe squamous precursor (pre-neoplastic) lesions in the vulva. (Medical Expert/Scholar)
2) Discuss the challenges in diagnosing vulvar squamous precursor on small biopsies using histology alone and reasons for frequent clinico-pathologic discrepancies. (Medical Expert/Scholar)
3) Describe the molecular pathogenesis of vulvar squamous cell carcinomas and its clinical relevance. (Medical Expert/Scholar)

Learning objectives:
1) Describe prognostic factors for vulvar cancer. (Medical Expert/Scholar)
2) Review vulvar contouring atlas for IMRT. (Medical Expert/Scholar)
3) Discuss the use of chemoradiation and radiation dose escalation for locally advanced vulvar cancer. (Medical Expert/Scholar)

Learning objectives: 
1) Illustrate the implications of an early diagnosis of menopause for the cancer patient. (Medical Expert/Scholar)
2) Discuss the role of menopausal hormone therapy in this patient population. (Medical Expert/Scholar)
3) Describe the potential risks of menopausal hormone therapy. (Medical Expert/Scholar)
4) Define an approach to prescribing hormone replacement to these patients. (Medical Expert/Scholar)

Learning objectives:
1) Describe the role radiation has played in ovarian cancer. (Medical Expert/Scholar)
2) Define: WART, IMRT and SBRT. (Medical Expert/Scholar)
3) Discuss the role of SBRT in the current paradigm of ovarian cancer management. (Medical Expert/Scholar)
4) Identify future opportunities to combine radiation and systemic treatments. (Scholar/Collaborator)

Learning objectives:
1) Describe the role of physiotherapy in the oncology gynecology patient. (Medical Expert/Scholar)
2) Describe and identify common pelvic floor dysfunctions in the oncology patient. (Medical Expert/Scholar)
3) Identify the appropriateness for oncology patient referrals to pelvic floor rehabilitation. (Medical Expert/Scholar)

Learning objectives:
1) To define the approved indications for immune checkpoint inhibitors across all cancers in the USA and Canada (Scholar).
2) To summarize the current and pending immunotherapy clinical trials in ovarian, endometrial and cervical cancers (Medical Expert/ Scholar)
3) To discuss opportunities for future collaboration as a Canadian collective in gynecologic cancer (Collaborator).

Learning objectives:
1) Explain the basic interplay between cancer and the immune system. (Medical Expert/Scholar)
2) Identify the common and uncommon toxicities of immunotherapy. (Medical Expert/Scholar)
3) Apply knowledge of toxicity to cases. (Medical Expert/Scholar)
4) Organize multi-disciplinary input into monitoring and treating IO toxicities. (Communicator/Collaborator/Health Advocate/Professional)